ACPT-I
- Product Name
- ACPT-I
- CAS No.
- 194918-76-8
- Chemical Name
- ACPT-I
- Synonyms
- ACPT-I;ACPT I,ACPTI;(1S,3R,4S)-1-AMINOCYCLOPENTANE-1,3,4-TRICARBOXYLIC ACID;4-AMINO-1BETA,2BETA,4BETA-CYCLOPENTANETRICARBOXYLIC ACID;1,2,4-Cyclopentanetricarboxylic acid, 4-amino-, (1α,2α,4β)-
- CBNumber
- CB6768791
- Molecular Formula
- C8H11NO6
- Formula Weight
- 217.18
- MOL File
- 194918-76-8.mol
ACPT-I Property
- Boiling point:
- 440.4±45.0 °C(Predicted)
- Density
- 1.651±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH
- form
- Powder
- pka
- 1.85±0.60(Predicted)
N-Bromosuccinimide Price
- Product number
- 78010
- Product name
- ACPT-I
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 78010
- Product name
- ACPT-I
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 78010
- Product name
- ACPT-I
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $235
- Updated
- 2024/03/01
- Product number
- 78010
- Product name
- ACPT-I
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- 1111
- Product name
- ACPT-I
- Packaging
- 10
- Price
- $228
- Updated
- 2021/12/16
ACPT-I Chemical Properties,Usage,Production
Description
ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 μM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 μM) reduces cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg. It is neuroprotective against excitotoxicity induced by kainite in vitro and in vivo and reduces the incidence of clonic seizures in various seizure models in mice and rats (ED50s = 0.08-49.3 nM, i.c.v.). ACPT-I also has anxiolytic-like effects in mice and rats, however, these effects can be blocked by WAY-100635 and flumazenil , indicating the involvement of the serotonin (5-HT) receptor subtype 5-HT1A and GABAA receptor.
Uses
ACPT-I is a competitive antagonist for metabotropic receptors (mGluRs).
Biological Activity
Agonist for group III mGlu receptors (EC 50 values are 7.2 and 8.2 μ M for mGlu 4a and mGlu 8 respectively). Anticonvulsant in mice.
storage
Desiccate at -20°C